منابع مشابه
From the Prague Spring to a chair in nephrology in Germany: Jan Brod (1912-1985).
An eminent clinician, teacher and scientist, Jan Brod (1912–1985) was among the founders of academic nephrology in post-war Europe. In particular, he pioneered the pathophysiological approach to kidney disease and hypertension. Today, Brod is nearly unknown to the younger generation of nephrologists, not least because few publications have dealt with his remarkable life. His journey through nep...
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We formulate a complete path integral bosonization procedure for any fermionic theory in two dimensions. The classical action of the bosons in the bosonized theory is −i times the logarithm of the Jacobian of a local chiral transformation, with the boson fields as transformation parameters. Three examples, the Schwinger model, the massive Thirring model and massive non-Abelian bosonization, are...
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The mechanism by which drugs inhibit organic anion transporter 1 (OAT1) was examined. OAT1 was stably expressed in Chinese hamster ovary (CHO) cells, and para-aminohippurate (PAH) and 6-carboxyfluorescein were the substrates. Most compounds (10 of 14) inhibited competitively, increasing the Michaelis constant (Km) without affecting the maximal transport rate (Jmax). Others were mixed-type (lowe...
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Autosomal dominant polycystic kidney disease (ADPKD) occurs by germline mutation in PKD1 or PKD2. Evidence of homozygous inactivation of either gene in human cyst lining cells as well as in mouse knockout models strongly supports a two-hit mechanism for cyst formation. Discovery of trans-heterozygous mutations in PKD1 and PKD2 in a minority of human renal cysts has led to the proposal that such...
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Motivation: Adoptive T cell therapies based on introduction of new T cell receptors (TCRs) into patient recipient T cells is a promising new treatment for various kinds of cancers. A major challenge, however, is the choice of target antigens. If an engineered TCR can cross-react with self-antigens in healthy tissue, the side-effects can be devastating. We present the first web server for assess...
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ژورنال
عنوان ژورنال: Antiquitates Mathematicae
سال: 2019
ISSN: 2353-8813,1898-5203
DOI: 10.14708/am.v12i1.6406